Essential Role Of High Glucose-Induced Overexpression Of PKCβ And PKCδ In GLP-1 Resistance In Rodent Cardiomyocytes

PURPOSE: Myocardia in diabetic patients exhibit increased vulnerability after ischemia/reperfusion injury (IRI). It has been demonstrated that glucagon-like peptide-1 (GLP-1) has a protective effect on cardiomyocytes. Protein kinase C (PKC) acts as a key regulator of many signaling pathways includin...

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Vydáno v:Diabetes Metab Syndr Obes
Hlavní autoři: Pan, Xietian, Chen, Jiangwei, Wang, Tingting, Zhang, Mingming, Wang, Haichang, Gao, Haokao
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839579/
https://ncbi.nlm.nih.gov/pubmed/31807042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S215789
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