Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS

In pharmaceutical industry, isepamicin is mainly manufactured from gentamicin B, which is produced by Micromonospora echinospora as a minor component of the gentamicin complex. Improvement of gentamicin B production through metabolic engineering is therefore important to satisfy the increasing deman...

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Bibliografische gegevens
Gepubliceerd in:Metab Eng Commun
Hoofdauteurs: Chang, Yingying, Chai, Baozhong, Ding, Yunkun, He, Min, Zheng, Linghui, Teng, Yun, Deng, Zixin, Yu, Yi, Liu, Tiangang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838515/
https://ncbi.nlm.nih.gov/pubmed/31720212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2019.e00096
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