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Contextualized genome-scale model unveils high-order metabolic effects of the specific growth rate and oxygenation level in recombinant Pichia pastoris

Pichia pastoris is recognized as a biotechnological workhorse for recombinant protein expression. The metabolic performance of this microorganism depends on genetic makeup and culture conditions, amongst which the specific growth rate and oxygenation level are critical. Despite their importance, onl...

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Detalhes bibliográficos
Publicado no:Metab Eng Commun
Main Authors: Torres, Paulina, Saa, Pedro A., Albiol, Joan, Ferrer, Pau, Agosin, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838487/
https://ncbi.nlm.nih.gov/pubmed/31720218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2019.e00103
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