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Contextualized genome-scale model unveils high-order metabolic effects of the specific growth rate and oxygenation level in recombinant Pichia pastoris

Pichia pastoris is recognized as a biotechnological workhorse for recombinant protein expression. The metabolic performance of this microorganism depends on genetic makeup and culture conditions, amongst which the specific growth rate and oxygenation level are critical. Despite their importance, onl...

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Vydáno v:Metab Eng Commun
Hlavní autoři: Torres, Paulina, Saa, Pedro A., Albiol, Joan, Ferrer, Pau, Agosin, Eduardo
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838487/
https://ncbi.nlm.nih.gov/pubmed/31720218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2019.e00103
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