Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9

BACKGROUND: Cartilaginous endplate (CEP) degeneration is considered as one of the major causes of intervertebral disc degeneration (IVDD) which causes low back pain. Recent studies have proved that epigenetic alteration is involved in a variety of diseases. This work explored the role of histone met...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Jiang, Chao, Guo, Qiang, Jin, Yu, Xu, Jia-Jing, Sun, Ze-Ming, Zhu, Ding-Chao, Lin, Jia-Hao, Tian, Nai-Feng, Sun, Liao-Jun, Zhang, Xiao-Lei, Wu, Yao-Sen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838408/
https://ncbi.nlm.nih.gov/pubmed/31631036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.006
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