TGFβ induces stemness through non-canonical AKT-FOXO3a axis in oral squamous cell carcinoma

BACKGROUND: FOXO3a has been widely regarded as a tumor suppressor. It also plays a paradoxical role in regulating the cancer stem cells (CSCs), responsible for tumor-initiation, chemo-resistance, and recurrence in various solid tumors, including oral squamous cell carcinoma (OSCC). This study aims t...

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Vydáno v:EBioMedicine
Hlavní autoři: Li, Kan, Yang, Le, Li, Jingyuan, Guan, Chenyu, Zhang, Sien, Lao, Xiaomei, Ouyang, Daiqiao, Zheng, Guangsen, Gao, Siyong, Wang, Dikan, Liang, Yujie, Liao, Guiqing
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Research paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838363/
https://ncbi.nlm.nih.gov/pubmed/31629677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.09.027
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