Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

The first example of a novel class of AMPA receptor positive allosteric modulators of the bis(pyrimidine) series having a hydroquinone linker has been obtained and showed a potency to increase kainate-induced currents at subnanomolar concentrations.

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Nazarova, Anna A., Sedenkova, Kseniya N., Karlov, Dmitry S., Lavrov, Mstislav I., Grishin, Yuri K., Kuznetsova, Tamara S., Zamoyski, Vladimir L., Grigoriev, Vladimir V., Averina, Elena B., Palyulin, Vladimir A.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837176/
https://ncbi.nlm.nih.gov/pubmed/31803402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00262f
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