Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically...

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Опубликовано в: :Nat Genet
Главные авторы: Jansen, Iris E, Savage, Jeanne E, Watanabe, Kyoko, Bryois, Julien, Williams, Dylan M, Steinberg, Stacy, Sealock, Julia, Karlsson, Ida K, Hägg, Sara, Athanasiu, Lavinia, Voyle, Nicola, Proitsi, Petroula, Witoelar, Aree, Stringer, Sven, Aarsland, Dag, Almdahl, Ina S, Andersen, Fred, Bergh, Sverre, Bettella, Francesco, Bjornsson, Sigurbjorn, Brækhus, Anne, Bråthen, Geir, de Leeuw, Christiaan, Desikan, Rahul S, Djurovic, Srdjan, Dumitrescu, Logan, Fladby, Tormod, Homan, Timothy J, Jonsson, Palmi V, Kiddle, Steven J, Rongve, K Arvid, Saltvedt, Ingvild, Sando, Sigrid B, Selbæk, Geir, Shoai, Maryam, Skene, Nathan, Snaedal, Jon, Stordal, Eystein, Ulstein, Ingun D, Wang, Yunpeng, White, Linda R, Hardy, John, Hjerling-Leffler, Jens, Sullivan, Patrick F, van der Flier, Wiesje M, Dobson, Richard, Davis, Lea K, Stefansson, Hreinn, Stefansson, Kari, Pedersen, Nancy L, Ripke, Stephan, Andreassen, Ole A, Posthuma, Danielle
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6836675/
https://ncbi.nlm.nih.gov/pubmed/30617256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0311-9
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