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Molecular basis for chirality-regulated Aβ self-assembly and receptor recognition revealed by ion mobility-mass spectrometry

Despite extensive efforts on probing the mechanism of Alzheimer’s disease (AD) and enormous investments into AD drug development, the lack of effective disease-modifying therapeutics and the complexity of the AD pathogenesis process suggest a great need for further insights into alternative AD drug...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Li, Gongyu, DeLaney, Kellen, Li, Lingjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834639/
https://ncbi.nlm.nih.gov/pubmed/31695027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12346-8
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