Brain Activation in a Cynomolgus Macaque Model of Chymopapain-Induced Discogenic Low Back Pain: A Preliminary Study

INTRODUCTION: There is currently a lack of translatable, preclinical models of low back pain (LBP). Chymopapain, a proteolytic enzyme used to treat lumbar intervertebral disc (IVD) herniation, could induce discogenic LBP. The current study developed a behavioral model of discogenic LBP in nonhuman p...

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Detalhes bibliográficos
Publicado no:Spine Surg Relat Res
Main Authors: Ushirozako, Hiroki, Yoshida, Go, Togawa, Daisuke, Omura, Takao, Hasegawa, Tomohiko, Yamato, Yu, Banno, Tomohiro, Arima, Hideyuki, Oe, Shin, Mihara, Yuki, Yamada, Tomohiro, Natsume, Takahiro, Ogawa, Shinya, Awaga, Yuji, Takamatsu, Hiroyuki, Matsuyama, Yukihiro
Formato: Artigo
Idioma:Inglês
Publicado em: The Japanese Society for Spine Surgery and Related Research 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834467/
https://ncbi.nlm.nih.gov/pubmed/31768458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22603/ssrr.2018-0110
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