Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution of drug resistance. We provide evidence that allel...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Chevalier, Frédéric D., Le Clec’h, Winka, McDew-White, Marina, Menon, Vinay, Guzman, Meghan A., Holloway, Stephen P., Cao, Xiaohang, Taylor, Alexander B., Kinung'hi, Safari, Gouvras, Anouk N., Webster, Bonnie L., Webster, Joanne P., Emery, Aidan M., Rollinson, David, Garba Djirmay, Amadou, Al Mashikhi, Khalid M., Al Yafae, Salem, Idris, Mohamed A., Moné, Hélène, Mouahid, Gabriel, Hart, P. John, LoVerde, Philip T., Anderson, Timothy J. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834289/
https://ncbi.nlm.nih.gov/pubmed/31652296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007881
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