Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction

Calcium (Ca(2+)) is a vital secondary messenger in T lymphocytes regulating a vast array of important events including maturation, homeostasis, activation, and apoptosis and can enter the cell through CRAC, TRP, and Ca(V) channels. Here we describe a mutation in the L-type Ca(2+) channel Ca(V)1.4 le...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Fenninger, Franz, Han, Jeffrey, Stanwood, Shawna R., Nohara, Lilian L., Arora, Hitesh, Choi, Kyung Bok, Munro, Lonna, Pfeifer, Cheryl G., Shanina, Iryna, Horwitz, Marc S., Jefferies, Wilfred A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833481/
https://ncbi.nlm.nih.gov/pubmed/31736943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02473
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