PD-1-Targeted Discovery of Peptide Inhibitors by Virtual Screening, Molecular Dynamics Simulation, and Surface Plasmon Resonance

The blockade of the programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) pathway plays a critical role in cancer immunotherapy by reducing the immune escape. Five monoclonal antibodies that antagonized PD-1/PD-L1 interaction have been approved by the Food and Drug Administrati...

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Veröffentlicht in:Molecules
Hauptverfasser: Wang, Yuanqiang, Guo, Haiqiong, Feng, Zhiwei, Wang, Siyi, Wang, Yuxuan, He, Qingxiu, Li, Guangping, Lin, Weiwei, Xie, Xiang-Qun, Lin, Zhihua
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833008/
https://ncbi.nlm.nih.gov/pubmed/31640203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24203784
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