Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction

The papain-like cysteine protease 2 (PLP2) within the N-terminus of the porcine reproductive and respiratory syndrome virus (PRRSV) nsp2 replicase protein specifies a deubiquitinating enzyme (DUB), but its biochemical properties and the role in infection have remained poorly defined. By using in vit...

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Publicado no:Viruses
Main Authors: Zhou, Shaochuan, Ge, Xinna, Kong, Can, Liu, Teng, Liu, Aijing, Gao, Peng, Song, Jiangwei, Zhou, Lei, Guo, Xin, Han, Jun, Yang, Hanchun
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6832237/
https://ncbi.nlm.nih.gov/pubmed/31561412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v11100896
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