Kartogenin hydrolysis product 4-aminobiphenyl distributes to cartilage and mediates cartilage regeneration

Rationale The small molecule Kartogenin (KGN) promotes cartilage regeneration in osteoarthritis (OA) by activating stem cells differentiation, but its pharmacological mode-of-action remains unclear. KGN can be cleaved into 4-aminobiphenyl (4-ABP) and phthalic acid (PA) following enzymolysis of an am...

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Detalles Bibliográficos
Publicado en:Theranostics
Main Authors: Zhang, Shuai, Hu, Peilin, Liu, Tao, Li, Zhen, Huang, Yongcan, Liao, Jinqi, Hamid, Md Rana, Wen, Liru, Wang, Ting, Mo, Cuiping, Alini, Mauro, Grad, Sibylle, Wang, Tianfu, Chen, Di, Zhou, Guangqian
Formato: Artigo
Idioma:Inglês
Publicado: Ivyspring International Publisher 2019
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831301/
https://ncbi.nlm.nih.gov/pubmed/31695756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.38182
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