Synergistic Genetic Interactions between Pkhd1 and Pkd1 Result in an ARPKD-Like Phenotype in Murine Models

BACKGROUND: Autosomal recessive polycystic kidney disease (ARPKD) and autosomal dominant polycystic kidney disease (ADPKD) are genetically distinct, with ADPKD usually caused by the genes PKD1 or PKD2 (encoding polycystin-1 and polycystin-2, respectively) and ARPKD caused by PKHD1 (encoding fibrocys...

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Udgivet i:J Am Soc Nephrol
Main Authors: Olson, Rory J., Hopp, Katharina, Wells, Harrison, Smith, Jessica M., Furtado, Jessica, Constans, Megan M., Escobar, Diana L., Geurts, Aron M., Torres, Vicente E., Harris, Peter C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2019
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830782/
https://ncbi.nlm.nih.gov/pubmed/31427367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019020150
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