Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance

Neonates at risk of childhood atopy and asthma exhibit perturbation of the gut microbiome, metabolic dysfunction and increased concentrations of 12,13-diHOME in their faeces. However, the mechanism, source and contribution of this lipid to allergic inflammation remain unknown. Here, we show that int...

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Bibliografiset tiedot
Julkaisussa:Nat Microbiol
Päätekijät: Levan, Sophia R., Stamnes, Kelsey A., Lin, Din L., Panzer, Ariane R., Fukui, Elle, McCauley, Katherine, Fujimura, Kei E., McKean, Michelle, Ownby, Dennis R., Zoratti, Edward M., Boushey, Homer A., Cabana, Michael D., Johnson, Christine C., Lynch, Susan V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830510/
https://ncbi.nlm.nih.gov/pubmed/31332384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0498-2
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