Arsenoplatin-1 is a Dual Pharmacophore Anti-Cancer Agent

Arsenoplatins are adducts of two chemically important anticancer drugs, cisplatin and arsenic trioxide, that have a Pt(II) bond to an As(III) hydroxide center. Screens of the NCI-60 human tumor cell lines reveal that arsenoplatin-1 (AP1), [Pt(μ-NHC(CH(3))O)(2)ClAs(OH)(2)], the first representative o...

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Publicat a:J Am Chem Soc
Autors principals: Miodragović, Đenana, Merlino, Antonello, Swindell, Elden P., Bogachkov, Abraham, Ahn, Richard W., Abuhadba, Sara, Ferraro, Giarita, Marzo, Tiziano, Mazar, Andrew P., Messori, Luigi, O’Halloran, Thomas V.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830503/
https://ncbi.nlm.nih.gov/pubmed/30943017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b13681
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