In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos

We investigated a panel of 14 compounds belonging to the monothiocarbamate (MTC) and dithiocarbamate (DTC) series against the β-carbonic anhydrase 3 (β-CA3) of Mycobacterium tuberculosis (Mtb). We also evaluated all compounds for toxicity using 1–5-day post fertilisation zebrafish embryos. 11 out of...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Aspatwar, Ashok, Hammaren, Milka, Parikka, Mataleena, Parkkila, Seppo, Carta, Fabrizio, Bozdag, Murat, Vullo, Daniela, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830242/
https://ncbi.nlm.nih.gov/pubmed/31663386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1683007
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