High-throughput structures of protein–ligand complexes at room temperature using serial femtosecond crystallography

High-throughput X-ray crystal structures of protein–ligand complexes are critical to pharmaceutical drug development. However, cryocooling of crystals and X-ray radiation damage may distort the observed ligand binding. Serial femtosecond crystallography (SFX) using X-ray free-electron lasers (XFELs)...

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Detalhes bibliográficos
Publicado no:IUCrJ
Main Authors: Moreno-Chicano, Tadeo, Ebrahim, Ali, Axford, Danny, Appleby, Martin V., Beale, John H., Chaplin, Amanda K., Duyvesteyn, Helen M. E., Ghiladi, Reza A., Owada, Shigeki, Sherrell, Darren A., Strange, Richard W., Sugimoto, Hiroshi, Tono, Kensuke, Worrall, Jonathan A. R., Owen, Robin L., Hough, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830213/
https://ncbi.nlm.nih.gov/pubmed/31709063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252519011655
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