Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells. Since histone deacetylase protein inhibitors demonstrate profound anti-inflammatory activity, we wanted to t...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Pharmacol
Päätekijät: Luque-Martin, Rosario, Van den Bossche, Jan, Furze, Rebecca C., Neele, Annette E., van der Velden, Saskia, Gijbels, Marion J.J., van Roomen, Cindy P.P.A., Bernard, Sharon G., de Jonge, Wouter J., Rioja, Inmaculada, Prinjha, Rab K., Lewis, Huw D., Mander, Palwinder K., de Winther, Menno P.J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2019
Aiheet:
Pharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830127/
https://ncbi.nlm.nih.gov/pubmed/31736752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01242
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