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ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma
Cancer is, fundamentally, a disorder of cell growth and proliferation, which requires adequate supplies of energy and nutrients. In this study, we report that the haplo-insufficient tumor suppressor ASPP2, a p53 activator, negatively regulates the mevalonate pathway to mediate its inhibitory effect...
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| Pubblicato in: | Cell Death Dis |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6828733/ https://ncbi.nlm.nih.gov/pubmed/31685796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2054-7 |
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