Astrocyte Infection Is Required for Retrovirus-Induced Spongiform Neurodegeneration Despite Suppressed Viral Protein Expression

The ability of retroviruses (RVs) to cause neurodegeneration is critically dependent upon two activities of the envelope protein (Env). First, Env facilitates viral genome delivery to CNS target cells through receptor binding and membrane fusion. Second, Env expression within one or more targets ind...

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Detalles Bibliográficos
Publicado en:Front Neurosci
Main Authors: Cardona, Sandra M., Dunphy, Jaclyn M., Das, Alvin S., Lynch, Connor R., Lynch, William P.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828646/
https://ncbi.nlm.nih.gov/pubmed/31736699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.01166
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