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Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes

Pulmonary veins (PVs) are the major origin of atrial fibrillation. Recently, we recorded hyperpolarization-activated Cl(−) current (I(Cl, h)) in rat PV cardiomyocytes. Unlike the well-known chloride channel protein 2 (CLCN2) current, the activation curve of I(Cl, h) was hyperpolarized as the Cl(−) i...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Okamoto, Yosuke, Nagasawa, Yoshinobu, Obara, Yutaro, Ishii, Kuniaki, Takagi, Daichi, Ono, Kyoichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827309/
https://ncbi.nlm.nih.gov/pubmed/31506297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007416
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