Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations

PURPOSE: While multimodal chemotherapy has improved outcomes for patients with osteosarcoma (OS), the prognosis for patients who present with metastatic and/or recurrent disease remains poor. In this study, we sought to define how often clinical genomic sequencing of OS samples could identify potent...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Suehara, Yoshiyuki, Alex, Deepu, Bowman, Anita, Middha, Sumit, Zehir, Ahmet, Chakravarty, Debyani, Wang, Lu, Jour, George, Nafa, Khedoudja, Hayashi, Takuo, Jungbluth, Achim A, Frosina, Denise, Slotkin, Emily, Shukla, Neerav, Meyers, Paul, Healey, John H., Hameed, Meera, Ladanyi, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825534/
https://ncbi.nlm.nih.gov/pubmed/31175097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-4032
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