Region-specific glucocorticoid receptor promoter methylation has both positive and negative prognostic value in patients with estrogen receptor-positive breast cancer

BACKGROUND: The glucocorticoid receptor (NR3C1, GR) is frequently downregulated in breast tumors, and evidence suggests it acts as a tumor suppressor in estrogen receptor-positive (ER+) breast cancer. We previously found that methylation of the GR promoter CpG island represses gene expression and oc...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Snider, Hilary, Villavarajan, Brithica, Peng, Yingwei, Shepherd, Lois E., Robinson, Andrew C., Mueller, Christopher R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825343/
https://ncbi.nlm.nih.gov/pubmed/31675993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0750-x
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