Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra-SRS, with autocrine IGF-1R activation and metastatic potential to the lungs

Approximately 60–70% of EWSR1-negative small blue round cell sarcomas harbour a rearrangement of CIC, most commonly CIC-DUX4. CIC-DUX4 sarcoma (CDS) is an aggressive and often fatal high-grade sarcoma appearing predominantly in children and young adults. Although cell lines and their xenograft model...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Nakai, Sho, Yamada, Shutaro, Outani, Hidetatsu, Nakai, Takaaki, Yasuda, Naohiro, Mae, Hirokazu, Imura, Yoshinori, Wakamatsu, Toru, Tamiya, Hironari, Tanaka, Takaaki, Hamada, Kenichiro, Tani, Akiyoshi, Myoui, Akira, Araki, Nobuhito, Ueda, Takafumi, Yoshikawa, Hideki, Takenaka, Satoshi, Naka, Norifumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825133/
https://ncbi.nlm.nih.gov/pubmed/31676869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52143-3
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