Alkyne Hydroheteroarylation: Enantioselective Coupling of Indoles and Alkynes via Rh-Hydride Catalysis

We report an enantioselective coupling between alkynes and indoles. A Rh-hydride catalyst isomerizes alkynes to generate a metal-allyl species that can be trapped with both aromatic and heteroaromatic nucleophiles.

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Cruz, Faben A., Zhu, Yamin, Tercenio, Quentin D., Shen, Zengming, Dong, Vy M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824589/
https://ncbi.nlm.nih.gov/pubmed/28742333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05893
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