PCSK9 loss-of-function variants and Lp(a) phenotypes among black US adults

The pharmacologic inhibition of proprotein convertase subtilisin-kexin type 9 (PCSK9) lowers lipoprotein (a) [Lp(a)] concentrations. However, the impact of genetic PCSK9 loss-of-function variants (LOFVs) on Lp(a) is uncertain. We determined the association of PCSK9 LOFVs with Lp(a) measures among bl...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Mefford, Matthew T., Marcovina, Santica M., Bittner, Vera, Cushman, Mary, Brown, Todd M., Farkouh, Michael E., Tsimikas, Sotirios, Monda, Keri L., López, J. Antonio G., Muntner, Paul, Rosenson, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Patient-Oriented and Epidemiological Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824493/
https://ncbi.nlm.nih.gov/pubmed/31511398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P119000173
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