Maximum Tolerated Dose and Pharmacokinetics of Paclitaxel Micellar in Patients with Recurrent Malignant Solid Tumours: A Dose-Escalation Study

INTRODUCTION: A water-soluble Cremophor EL-free formulation of paclitaxel, in which retinoic acid derivates solubilize paclitaxel by forming micelles (paclitaxel micellar), was studied for the first time in man to establish the maximum tolerated dose (MTD) and to characterize the pharmacokinetics (P...

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Bibliographic Details
Published in:Adv Ther
Main Authors: Borgå, Olof, Henriksson, Roger, Bjermo, Helena, Lilienberg, Elsa, Heldring, Nina, Loman, Niklas
Format: Artigo
Language:Inglês
Published: Springer Healthcare 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824363/
https://ncbi.nlm.nih.gov/pubmed/30879251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12325-019-00909-6
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