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A green and facile synthesis of an industrially important quaternary heterocyclic intermediates for baricitinib
BACKGROUND: Baricitinib, with a 2-(1-(ethylsulfonyl)azetidin-3-yl)acetonitrile moiety at N-2 position of the pyrazol skeleton, is an oral and selective reversible inhibitor of the JAK1 and JAK2 and displays potent anti-inflammatory activity. Several research-scale synthetic methods have been reporte...
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| Publicat a: | BMC Chem |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer International Publishing
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6824028/ https://ncbi.nlm.nih.gov/pubmed/31696160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-019-0639-y |
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