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Homotaurine Treatment Enhances CD4(+) and CD8(+) Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice
Immune cells express γ-aminobutyric acid receptors (GABA-R), and GABA administration can inhibit effector T cell responses in models of autoimmune disease. The pharmacokinetic properties of GABA, however, may be suboptimal for clinical applications. The amino acid homotaurine is a type A GABA-R (GAB...
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| Publicado no: | Immunohorizons |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6823932/ https://ncbi.nlm.nih.gov/pubmed/31636084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/immunohorizons.1900019 |
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