Monolayer Sensitivity Enables a 2D IR Spectroscopic Immuno-biosensor for Studying Protein Structures: Application to Amyloid Polymorphs

Immunosensors use antibodies to detect and quantify biomarkers of disease, though the sensors often lack structural information. We create a surface-sensitive two-dimensional infrared (2D IR) spectroscopic immunosensor for studying protein structures. We tether antibodies to a plasmonic surface, flo...

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Publicat a:J Phys Chem Lett
Autors principals: Ostrander, Joshua S., Lomont, Justin P., Rich, Kacie L., Saraswat, Vivek, Feingold, Benjamin R., Petti, Megan K., Birdsall, Erin R., Arnold, Michael S., Zanni, Martin T.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823637/
https://ncbi.nlm.nih.gov/pubmed/31246039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.9b01267
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