Inhibition of immune checkpoints prevents injury-induced heterotopic ossification

Heterotopic ossification (HO), true bone formation in soft tissue, is closely associated with abnormal injury/immune responses. We hypothesized that a key underlying mechanism of HO might be injury-induced dysregulation of immune checkpoint proteins (ICs). We found that the earliest stages of HO are...

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Detalhes bibliográficos
Publicado no:Bone Res
Main Authors: Kan, Chen, Yang, Jiazhao, Na, Ding, Xu, Yuanhong, Yang, Baixia, Zhao, Haodong, Lu, Huadong, Li, Yuyun, Zhang, Keqin, McGuire, Tammy L., Kessler, John A., Kan, Lixin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823457/
https://ncbi.nlm.nih.gov/pubmed/31700694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-019-0074-7
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