GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway

BACKGROUND: Glutathione S-transferase zeta 1 (GSTZ1) is the penultimate enzyme in phenylalanine/tyrosine catabolism. GSTZ1 is dysregulated in cancers; however, its role in tumorigenesis and progression of hepatocellular carcinoma (HCC) is largely unknown. We aimed to assess the role of GSTZ1 in HCC...

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Dades bibliogràfiques
Publicat a:J Exp Clin Cancer Res
Autors principals: Li, Jingjing, Wang, Qiujie, Yang, Yi, Lei, Chong, Yang, Fan, Liang, Li, Chen, Chang, Xia, Jie, Wang, Kai, Tang, Ni
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6822483/
https://ncbi.nlm.nih.gov/pubmed/31666108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1459-6
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