Arabidopsis thaliana alternative dehydrogenases: a potential therapy for mitochondrial complex I deficiency? Perspectives and pitfalls

BACKGROUND: Complex I (CI or NADH:ubiquinone oxidoreductase) deficiency is the most frequent cause of mitochondrial respiratory chain defect. Successful attempts to rescue CI function by introducing an exogenous NADH dehydrogenase, such as the NDI1 from Saccharomyces cerevisiae (ScNDI1), have been r...

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Detalhes bibliográficos
Publicado no:Orphanet J Rare Dis
Main Authors: Catania, Alessia, Iuso, Arcangela, Bouchereau, Juliette, Kremer, Laura S., Paviolo, Marina, Terrile, Caterina, Bénit, Paule, Rasmusson, Allan G., Schwarzmayr, Thomas, Tiranti, Valeria, Rustin, Pierre, Rak, Malgorzata, Prokisch, Holger, Schiff, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821020/
https://ncbi.nlm.nih.gov/pubmed/31665043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-019-1185-3
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