Variation of PEAR1 DNA methylation influences platelet and leukocyte function

BACKGROUND: Platelet-endothelial aggregation receptor 1 (PEAR-1) is a transmembrane receptor involved in platelet activation and megakaryopoiesis whose expression is driven by DNA methylation. PEAR1 variants were associated with differential platelet response to activation and cardiovascular outcome...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Izzi, Benedetta, Gianfagna, Francesco, Yang, Wen-Yi, Cludts, Katrien, De Curtis, Amalia, Verhamme, Peter, Di Castelnuovo, Augusto, Cerletti, Chiara, Donati, Maria Benedetta, de Gaetano, Giovanni, Staessen, Jan A., Hoylaerts, Marc F., Iacoviello, Licia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820903/
https://ncbi.nlm.nih.gov/pubmed/31665082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0744-8
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