Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset

Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Mutations in MFN2 cause the neurodegenerative disease Charcot-Marie-Tooth type 2A (CMT2A). The molecular basis underlying the physiological and pathological relevance of MFN2...

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I publikationen:Nat Commun
Huvudupphovsmän: Li, Yu-Jie, Cao, Yu-Lu, Feng, Jian-Xiong, Qi, Yuanbo, Meng, Shuxia, Yang, Jie-Feng, Zhong, Ya-Ting, Kang, Sisi, Chen, Xiaoxue, Lan, Lan, Luo, Li, Yu, Bing, Chen, Shoudeng, Chan, David C., Hu, Junjie, Gao, Song
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820788/
https://ncbi.nlm.nih.gov/pubmed/31664033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12912-0
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