Aβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism

Emerging evidences suggest that phospholipid metabolism is altered in Alzheimer’s disease (AD), but molecular mechanisms on how this affects neurodegeneration in AD is poorly understood. SHIP2 is a phosphoinositide-metabolizing enzyme, which dephosphorylates PI(3,4,5)P(3) resulting to PI(3,4)P(2), a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lee, Hae Nim, Sim, Kyoung Mi, Kim, Hyunbin, Ju, Jeongmin, Pae, Ae Nim, Park, Jae-Bong, Ryu, Hoon, Seong, Jihye
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820556/
https://ncbi.nlm.nih.gov/pubmed/31664099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51914-2
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