GPR40 activation initiates store-operated Ca(2+) entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells

The long-chain fatty acid receptor GPR40 plays an important role in potentiation of glucose-induced insulin secretion (GIIS) from pancreatic β-cells. Previous studies demonstrated that GPR40 activation enhances Ca(2+) release from the endoplasmic reticulum (ER) by activating inositol 1,4,5-triphosph...

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Udgivet i:Sci Rep
Main Authors: Usui, Ryota, Yabe, Daisuke, Fauzi, Muhammad, Goto, Hisanori, Botagarova, Ainur, Tokumoto, Shinsuke, Tatsuoka, Hisato, Tahara, Yumiko, Kobayashi, Shizuka, Manabe, Toshiya, Baba, Yoshihiro, Kurosaki, Tomohiro, Herrera, Pedro Luis, Ogura, Masahito, Nagashima, Kazuaki, Inagaki, Nobuya
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820554/
https://ncbi.nlm.nih.gov/pubmed/31664108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52048-1
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