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Downregulation of GRK5 hampers the migration of breast cancer cells

Sunitinib is a multispecific kinase inhibitor and one of its targets is the kinase GRK5, which is regulating a multitude of G protein-coupled receptors (GPCRs). In this study we demonstrate that a decreased GRK5 expression induced by knock-down experiments or sunitinib treatment hampers the migratio...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sommer, Ann-Katrin, Falcenberg, Mathias, Ljepoja, Bojan, Fröhlich, Thomas, Arnold, Georg J., Wagner, Ernst, Roidl, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820534/
https://ncbi.nlm.nih.gov/pubmed/31664083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51923-1
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