Tyr82 Amino Acid Mutation in PB1 Polymerase Induces an Influenza Virus Mutator Phenotype

In various positive-sense single-stranded RNA viruses, a low-fidelity viral RNA-dependent RNA polymerase (RdRp) confers attenuated phenotypes by increasing the mutation frequency. We report a negative-sense single-stranded RNA virus RdRp mutant strain with a mutator phenotype. Based on structural da...

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Udgivet i:J Virol
Main Authors: Naito, Tadasuke, Shirai, Kazumasa, Mori, Kotaro, Muratsu, Hidetaka, Ushirogawa, Hiroshi, Ohniwa, Ryosuke L., Hanada, Kousuke, Saito, Mineki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819930/
https://ncbi.nlm.nih.gov/pubmed/31462570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00834-19
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