CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

BACKGROUND: CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and is upregulated in osteosarcoma cell lines, but its functional role in osteosarcoma is still unknown. This study aimed to clarify the mechanism of circMYO10 in osteosarcoma. METHODS: CircMYO10 expression in 10 paired...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Chen, Junxin, Liu, Gang, Wu, Yizheng, Ma, Jianjun, Wu, Hongfei, Xie, Ziang, Chen, Shuai, Yang, Yute, Wang, Shengyu, Shen, Panyang, Fang, Yifan, Fan, Shunwu, Shen, Shuying, Fang, Xiangqian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819556/
https://ncbi.nlm.nih.gov/pubmed/31665067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-019-1076-1
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