Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression

Cancer-associated fibroblasts (CAFs) are key actors in modulating the progression of many solid tumors, such as breast cancer (BC). Herein, we identify an integrin α11/PDGFRβ–positive CAF subset displaying tumor-promoting features in BC. In the preclinical MMTV-PyMT mouse model, integrin α11 deficie...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Primac, Irina, Maquoi, Erik, Blacher, Silvia, Heljasvaara, Ritva, Van Deun, Jan, Smeland, Hilde Y.H., Canale, Annalisa, Louis, Thomas, Stuhr, Linda, Sounni, Nor Eddine, Cataldo, Didier, Pihlajaniemi, Taina, Pequeux, Christel, De Wever, Olivier, Gullberg, Donald, Noel, Agnès
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819106/
https://ncbi.nlm.nih.gov/pubmed/31287804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125890
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