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Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression
Cancer-associated fibroblasts (CAFs) are key actors in modulating the progression of many solid tumors, such as breast cancer (BC). Herein, we identify an integrin α11/PDGFRβ–positive CAF subset displaying tumor-promoting features in BC. In the preclinical MMTV-PyMT mouse model, integrin α11 deficie...
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| Veröffentlicht in: | J Clin Invest |
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6819106/ https://ncbi.nlm.nih.gov/pubmed/31287804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125890 |
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