Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema

The majority of patients with diabetic macular edema (DME), the most common cause of vision loss in working-age Americans, do not respond adequately to current therapies targeting VEGFA. Here, we show that expression of angiopoietin-like 4 (ANGPTL4), a HIF-1–regulated gene product, is increased in t...

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Publicat a:J Clin Invest
Autors principals: Sodhi, Akrit, Ma, Tao, Menon, Deepak, Deshpande, Monika, Jee, Kathleen, Dinabandhu, Aumreetam, Vancel, Jordan, Lu, Daoyuan, Montaner, Silvia
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819094/
https://ncbi.nlm.nih.gov/pubmed/31545295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120879
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