PTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients

BACKGROUND: CD40 is a costimulatory molecule for B cells, and CD154 is a marker of CD4+ T cells activation. CD40‐CD154 interaction promotes pro‐inflammatory cytokines secretion and autoantibodies production. PTPN22 gene encodes LYP protein, an inhibitor of T‐ and B‐cell activation. PTPN22 1858C>T...

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Detalhes bibliográficos
Publicado no:J Clin Lab Anal
Main Authors: Ruiz‐Noa, Yeniley, Hernández‐Bello, Jorge, Llamas‐Covarrubias, Mara A., Palafox‐Sánchez, Claudia A., Oregon‐Romero, Edith, Sánchez‐Hernández, Pedro Ernesto, Ramírez‐Dueñas, Maria Guadalupe, Parra‐Rojas, Isela, Muñoz‐Valle, Jose Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818609/
https://ncbi.nlm.nih.gov/pubmed/30402903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcla.22710
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