Synthesis and immunomodulatory activity of fluorine-containing bisphosphonates

Immune checkpoint blockade using anti-PD-1/-PD-L1 or anti-CTLA-4 monoclonal antibodies (mAbs) has revolutionized cancer treatment. However, many types of cancer do not respond and for those that do, only a minority of patients achieve durable remissions. Therefore, oncoimmunologists are working to d...

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Publicado en:ChemMedChem
Main Authors: Mizuta, Satoshi, Tagod, Mohammed S. O., Iwasaki, Masashi, Nakamura, Yoichi, Senju, Hiroaki, Mukae, Hiroshi, Morita, Craig T., Tanaka, Yoshimasa
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818088/
https://ncbi.nlm.nih.gov/pubmed/30637982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800764
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