Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1

Finding novel targets in non-small cell lung cancer (NSCLC) is highly needed and identification of synthetic lethality between two genes is a new approach to target NSCLC. We previously found that TMPRSS4 promotes NSCLC growth and constitutes a prognostic biomarker. Here, through large-scale analyse...

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Publicado no:Sci Rep
Main Authors: Villalba, Maria, Redin, Esther, Exposito, Francisco, Pajares, Maria Jose, Sainz, Cristina, Hervas, David, Guruceaga, Elizabeth, Diaz-Lagares, Angel, Cirauqui, Cristina, Redrado, Miriam, Valencia, Karmele, de Andrea, Carlos, Jantus-Lewintre, Eloisa, Camps, Carlos, Lopez-Lopez, Rafael, Lahoz, Agustin, Montuenga, Luis, Pio, Ruben, Sandoval, Juan, Calvo, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817908/
https://ncbi.nlm.nih.gov/pubmed/31659178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51066-3
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