Genetic Landscape of Somatic Mutations in a Large Cohort of Sporadic Medullary Thyroid Carcinomas Studied by Next-Generation Targeted Sequencing

Sporadic Medullary Thyroid Carcinoma (sMTC) is a rare but aggressive thyroid tumor. RET and RAS genes are present in about 50%–80% of cases, but most of the remaining cases are still orphan of a genetic driver. We studied the largest series of sMTC by deep sequencing to define the mutational landsca...

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Xehetasun bibliografikoak
Argitaratua izan da:iScience
Egile Nagusiak: Ciampi, Raffaele, Romei, Cristina, Ramone, Teresa, Prete, Alessandro, Tacito, Alessia, Cappagli, Virginia, Bottici, Valeria, Viola, David, Torregrossa, Liborio, Ugolini, Clara, Basolo, Fulvio, Elisei, Rossella
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817656/
https://ncbi.nlm.nih.gov/pubmed/31605946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.09.030
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