Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo

Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4(KI)), based on a published mutation in patients with...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:iScience
Prif Awduron: Bullock, Whitney A., Hoggatt, April M., Horan, Daniel J., Elmendorf, Andrew J., Sato, Amy Y., Bellido, Teresita, Loots, Gabriela G., Pavalko, Fredrick M., Robling, Alexander G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817631/
https://ncbi.nlm.nih.gov/pubmed/31585407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.09.023
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