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Activating and Repressing IRE1α: The Hsp47 and BiP Tug of War
In this issue, Sepulveda et al. (2018) discovered an interesting role of Hsp47 in regulating the unfolded protein response (UPR) wherein Hsp47 binds to IRE1α and displaces BiP, thereby activating the IRE1α arm of the UPR pathway by a previously undetermined mechanism.
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| Publicado en: | Mol Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6816461/ https://ncbi.nlm.nih.gov/pubmed/29351839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.032 |
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